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Assistant Professor of Biology MHC 175 Honors College, FAU 5353 Parkside Drive Jupiter, FL 33458 (561) 799-8676; (561) 799-8602 (fax) pkirchma@fau.edu Office
Hours for Fall 2001:
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Genetics - Fall Semester 2001, Tuesday and Thursday, 2:00 - 3:50, MAC 204. Syllabus
Biological Principles - Fall Semester 2001, Tuesday and Thursday, 11:00 - 12:20, MAC 122 Syllabus
Microbiology an Microbiology Lab - Spring 2002
Scientific Writing II - Spring 2002
Education, Research, and Work Experience
Assistant Professor of Biology, Honors
College
August 1999 – Present, Florida Atlantic University
Research topic: Mitochondrial influences on the replicative life span of
Saccharomyces
cerevisiae
Post-doctoral Fellow, Department of Biochemistry and Molecular Biology
May 1994 – June 1999, Louisiana State University Medical Center
Research topic: Replicative life span of Saccharomyces cerevisiae
Advisor: Dr. S. Michal Jazwinski
Post-doctoral Research, Center of Marine Biotechnology
October 1992 - March 1994, University of Maryland, College Park, MD
Research topics: Helicobacter pylori, viable but non-culturable bacteria
Advisors: Dr. Manoucher Shahamat & Dr. Rita Colwell
Doctor of Philosophy, Department of Microbiology and Immunology
July 1987 - October 1992, Emory University, Atlanta, Georgia
Dissertation title: Regulation of sigma Factor Activity in Bacillus
subtilis
Advisor: Dr. Charles P. Moran Jr.
Bachelor of Science, Biology (Honors)
August 1983 - May 1987, Eckerd College, St. Petersburg, Florida
Thesis title: The Isolation of Arginine Binding Proteins Solubilized
from
Cultured Human Fibroblast Plasma Membranes
Mentor: Dr. William Roess
Research Associate, Marine Science Program
Summer 1985, University of South Florida, St. Petersburg, Florida
Project: Collection of marine samples for a baseline study
Advisor: Dr. Norman Blake
Awards and Honors
Co-PI on NSF CCLI-Adaptation and Implementation Grant, “Discovery-Based Science and Mathematics in an Environmental Context” (NSF-0088211) - $187,054.00, Start Date May 15, 2001.
Research Initiation Award, Florida Atlantic University, “Analysis of the Relationship Between Mitochondrial Genotype and Longevity in Saccharomyces cerevisiae” (RIA-21), March, 2000
National Research Service Award, Individual Postdoctoral Fellowship, National Institutes of Health , “Role of a LAG1 homologue in Yeast Replicative Life Span.” (AG05710), September, 1995
Eckerd College Scholarship and Service Award, May, 1987
Bausch and Lomb Honorary Science Award, May, 1983
Professional Activities
Invited speaker, “Mitochondrial DNA and Aging” Science in Progress Seminar Series, Center for Molecular Biology and Biotechnology, Florida Atlantic University, November 15th, 2000.
Invited Speaker, “Increased Metabolic Capacity and Delayed Senescence in Yeast.”, 98th General Meeting of the American Society for Microbiology, Atlanta, Georgia, May 19th, 1998.
Invited Speaker, “Intracellular Communication: A Determinant of Yeast Longevity.”, Gordon Research Conference on the Biology of Aging, Il Ciocco, Italy, May 14th, 1998.
Invited Speaker, “Prohibitin, Ras, and Mitochondria.”, New Orleans Area Yeast Meeting, Tulane University, November 26th, 1996.
Member of the American Society for Microbiology.
Publications
Guillas, I., Kirchman, P.A., Chuard, R., Pfefferli M., Jiang, J.C., Jazwinski, S.M., and Conzelmann, A. (2001) Acyl-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J. 20: 2655-2665.
Kirchman, P.A., S. Kim, and S.M. Jazwinski.(1999) Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics 152: 179-109.
Kim, S., P.A. Kirchman, A Benguria, and S.M. Jazwinski. (1999). Experimentation with the yeast model. in Methods in Aging Research. (B.P. Yu ed.), CRC Press, Boca Raton, pp. 191-213.
Shama, S., P.A. Kirchman, J.C. Jiang, and S.M. Jazwinski. (1998). Role of RAS2 in recovery from chronic stress: effect on yeast life span. Exp. Cell Res. 245: 368-378.
Jiang, J.C., P.A. Kirchman, M Zagulski, J. Hunt, and S.M. Jazwinski. (1998). Homologues of the yeast longevity gene LAG1 in C. elegans and human. Genome Res. 8: 1259-1272.
Kim, S., J.C. Jiang, P.A. Kirchman, I. Rubelj, E.G. Helm, and S.M. Jazwinski. (1998). Cellular and Molecular Aging. in Comprehensive Geriatric Oncology, second edition, (L. Balducci, W.B. Ershler, G.H. Lyman, eds.) Harwood Academic Publishers. pp. 123-155.
Rahman, I., M. Shahamat, P.A. Kirchman, E. Russek-Cohen, and R.R. Colwell. (1994). Methionine uptake and cytopathogenicity of viable but nonculturable Shigella dysenteriae Type 1. Appl. Environ. Microbiol. 60: 3573-3578.
Kirchman, P.A., H. DeGrazia, E.M. Kellner, and C.P. Moran Jr. (1993). Forespore-specific disappearance of the sigma-factor antagonist SpoIIAB: implications for its role in determination of cell fate in Bacillus subtilis. Mol. Microbiol. 8: 663-671.
Satola, S., P.A. Kirchman, and C.P. Moran Jr. (1991). Spo0A binds to a promoter used by a sigmaA RNA polymerase during sporulation in Bacillus subtilis. Proc. Natl. Acad. Sci. 88: 4533-4537.
Kenney, T.J., P.A. Kirchman, and C.P. Moran Jr. (1988). Gene encoding sigmaE is transcribed from a sigmaA-like promoter in Bacillus subtilis. J. Bacteriol. 170: 3085-3064.
Scott, J.R., P.A. Kirchman, and M.G. Caparon. (1988). An intermediate
in transposition of the conjugative transposon Tn916. Proc. Natl.
Acad. Sci. 85: 4809-4813.
Abstracts
Kirchman, P. A. (2001) Growth Medium and Mitochondrial Genotype Influence Replicative Lifespan in Saccharomyces cerevisiae. American Society for Microbiology 101st General Meeting. May 20-24, 2001, Orlando, Florida.
Jazwinski S.M., P.A. Kirchman, R.L. West, J.C. Jiang, S. Kim, C.-Y. Lai, A. Benguria, and S. Shama. (1998). Longevity determining processes in Yeast. Meeting on Genetics of Aging, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, p. 3.
Jazwinski S.M., P.A. Kirchman, R.L. West, S. Kim, J.C. Jiang, S. Shama, C.-Y. Lai, and A. Benguria. (1998). Genes responsible for longevity in yeast. 29th Annual Meeting of the American Society for Neurochemistry, Denver, Colorado.
Jazwinski S.M., P.A. Kirchman, S. Kim, S. Shama, J.C. Jiang, R.L. West, C.-Y. Lai, and A. Benguria. (1997). Genes of Youth: Genetic analysis of Aging using yeast. The Gerontologist 37: 47.
Kirchman, P.A., S. Shama, R.L. West, S. Kim and S.M. Jazwinski. (1997). Interaction of factors affecting the life span of Saccharomyces cerevisiae. Mol. Biol. Cell. 8: 151a.
Kirchman, P.A., J.C. Jiang, S. Kim, R. West, and S.M. Jazwinski. (1997). Interaction of PHB1 and RAS2 with mitochondria in determining yeast life span. Cold Spring Harbor Laboratory Meeting on Yeast Cell Biology. Cold Spring Harbor, New York. p. 202.
Jazwinski, S.M., P.A. Kirchman, S. Kim, S. Shama, J.C. Jiang, R.L. West, C-Y Lai, A. Benguria. (1997). Genes of Youth: Genetic Analysis of Aging Using Yeast. 16th Congress of the International Association of Gerontology, Adelaide, Australia. p. 28-29.
Jazwinski, S.M., P.A. Kirchman, S. Kim, S. Shama, J.C. Jiang, R.L. West, C-Y Lai, A. Benguria. (1997). Signal Transduction and Yeast longevity: A Genetic Analysis. 16th Congress of the International Association of Gerontology, Singapore Pre Congress Satellite, Singapore. p. 21-22.
West, R., P.A. Kirchman, S.M. Jazwinski. (1997). The effect of the Saccharomyces cerevisiae PHB2 gene on Yeast longevity, Southeast Regional Yeast Meeting. University of Southern Mississippi Gulf Park Conference Center, Long Beach, Mississippi. p. 8.
Kirchman, P.A., J.C. Jiang, S. Kim, and S.M. Jazwinski. (1997). Association of Aging and Mitochondrial Function Revealed by Yeast PHB1. Gordon Conference on Biology of Aging. Ventura, California.
S.M. Jazwinski, P.A. Kirchman, S. Kim, J.C. Jiang, S. Shama, J.G. Delamatre, R.L. West, C-Y. Lai, A. Benguria. (1996). Longevity, genes, and aging from the perspective of a Yeast. Mol. Biol. Cell. 7: 7a.
Kirchman, P.A. and S.M. Jazwinski. (1996). LAG1 and LAC1 are homologous genes involved in determining the replicative life span of the budding yeast, Saccharomyces cerevisiae. FASEB J. 10: A1517.
Kirchman, P.A., S. Kim, and S. Michal Jazwinski. (1996) Prohibitin, Mitochondria and RAS2 in Yeast Longevity. Southeast Regional Yeast Meeting. University of Southern Mississippi, Hattiesburg, Mississippi. p. 8.
Kirchman, P.A. and S.M. Jazwinski. (1996). LAG1 and LAC1 are homologous genes involved in determining the replicative life span of the budding yeast, Saccharomyces cerevisiae. 96th General Meeting, American Society for Microbiology. New Orleans, Louisiana. p. 519.
Kirchman, P.A., B. Royals, D. Franklin, J. Sun, S. Kale, and S.M. Jazwinski. (1995). Genetic analysis of longevity in Yeast. Southeast Regional Yeast Meeting, University of Southern Mississippi, Hattiesburg, Mississippi. p. 20.
Kirchman, P.A., R. Coppolecchia, H. Degrazia, and C.P. Moran Jr. (1991). Two roles for SpoIIAB in sporulating Bacillus subtilis. The Sixth International Conference on Genetics and Biotechnology of Bacilli. Stanford University, California. p. W-16
Satola, S., P.A. Kirchman, and C.P. Moran Jr. (1991). Spo0A binds to a promoter used by sigmaA RNA polymerase during sporulation in Bacillus subtilis. 91st General Meeting, American Society for Microbiology, Dallas, Texas.
Moran, C.P., S. Satola, T.J. Kenney, R. Coppolecchia, H. DeGrazia, and P.A. Kirchman. (1990). Regulation and roles of stage II genes during endospore development. International Conference on the Bacillus subtilis genome. Paris, France.
Kenney, T.J., P.A. Kirchman, S. Satola, and C.P. Moran Jr. (1989).
Transcription of the spoIIG operon in Bacillus subtilis.
The Fifth International Conference on Genetics and Biotechnology of Bacilli.
Pacific Grove, California. p. W-7
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