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Life Sciences | Novel Anti-Inflammatory Agents from Pseudopterogorgia 
Description New potent anti-inflammatory agents have been identified from the marine coral Pseudopterogorgia elisabethae collected in the Florida Keys. The compounds include novel pseudopterosins, seco-pseudopterosins and elisabethadione. Advantages - Compounds exhibit potent anti-inflammatory, anti-proliferative and analgesic activity when administered to a subject.
- Seco-pseudopterosins and elisabethadione are structurally simpler than the pseudopterosins and thus are easier to synthesize.
- Some of the new compounds are more potent than the currently used pseudopterosins A and E.
- Compounds are of non-animal origin.
Potential Applications - May be used to treat, prevent, or inhibit rheumatoid arthritis, osteoarthritis, rheumatic carditis, collagen and auto-immune diseases such as myasthenia gravis, allergic diseases, bronchial asthma and ocular, skin inflammatory diseases such as poison ivy, and proliferative diseases such as psoriasis.
- Useful as adjuvant therapy associated with organ and tissue transplants and any neurological disease involving the metabolism of nervous tissue phospholipid such as multiple sclerosis.
- Can be useful in the treatment of insect bites, bee or wasp stings or any venom in which a major constituent is the enzyme phospholipse A2
Pseudopterogorgia elisabethae
(c) Florida Atlantic University All rights reserved.
Updated August 10, 2008 |
| Inventors
Dr. Russell G. Kerr
Professor of Chemistry and Biochemistry IP Status
U.S. Patent 6,787,571
Issued 9/7/04
U.S. Div Patent App
Filed 8/2/2004
AU Pat App 2002241521
Filed 5/28/2003
EU Pat App 01988191.1 Contact Information
Office of Technology Transfer
777 Glades Road, ADM 218
Boca Raton, FL 33431-0991 Kurt R. Moore
Assistant V.P. & Director
Ph: 561-297-1165
Fax: 561-297-2141
kmoore34@fau.edu Michelle Webb
Assistant Director
Ph: 561-297-0673
Fax: 561-297-2141
mwebb18@fau.edu Case Number
2000-18
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